Prof. Wang has long been engaged in clinical practice, teachings and research on respiratory problems such as pulmonary embolism, pulmonary hypertension, respiratory failure, pulmonary heart disease, chronic obstructive pulmonary diseases (COPD, Chronic Bronchitis Emphysema), new respiratory infectious diseases and tobacco epidemiology. He has achieved many important innovations including thrombolysis therapy and sequential mechanical ventilation, which have been adopted to the international treatment guidelines. He is in charge of multiple national research projects and international programs.
Prof. Wang has published more than 100 articles in international authoritative medical journals, such as the New England Journal of Medicine, The Lancet and Annals of Internal Medicine (Ann Intern Med). He has been honored as the Second Prize (three times), the First Prize (once) and the Special-class Prize (once) of the National Science and Technology Progress Award, and has received the Scientific and Technological Progress Award of the Ho Leung Ho Lee Foundation and the Outstanding Contribution Award for Tobacco Control of WHO, etc.
Prof. Wang has made impressive progress in disciplinary construction and hospital management when he served as senior administrator of medical institutions including the Beijing Chao-Yang Hospital, Beijing Hospital and the China-Japan Friendship Hospital. He once worked as the Deputy Director-General of the Department of Health Sciences, Technology and Education of China‘s National Health and Family Planning Commission (NHFPC), presiding over the department by promoting medical education and research at the national level.
Prof. Wang's key academic appointments:
Senior specialist in complicated and critical respiratory system diseases
Academician of the Chinese Academy of Engineering
Director, National respiratory clinical research center
Leader, National Key Disciplines for Respiratory Medicine
Leader, Innovation Team in respiratory and pulmonary circulation disorders of Ministry of Science and Technology
Vice President, Chinese Medical Doctor Association
President, China Respiratory Association of Chinese Medical Doctor Association
Vice President, Chinese Hospital Association
Honorary President, Chinese Society of Respiratory Disease of Chinese Medical Association
Honorary Fellow of the Department of Medicine at Imperial College London
Editor in chief, Chinese Medical Journal
Editor in chief, Clinical Respiratory Journal
1. Cao X. Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease. Nat Rev Immunol. 2016; 16(1):35-50. [PubMed]
2. Liu J, Qian C, Cao X. Post-Translational Modification Control of Innate Immunity. Immunity. 2016; 45(1):15-30. [PubMed]
3. Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang B, Xu X, Zheng J, Cao X. Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils. Cancer Cell. 2016; 30(2):243-256. [PubMed]
4. Liu Y, Cao X. Characteristics and Significance of the Pre-metastatic Niche. Cancer Cell. 2016; 30(5):668-681. [PubMed]
5. Li X, Zhang Q, Ding Y, Liu Y, Zhao D, Zhao K, Shen Q, Liu X, Zhu X, Li N, Cheng Z, Fan G, Wang Q, Cao X. Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity. Nat Immunol. 2016; 17(7):806-815. [PubMed]
6. Ding Y, Guo Z, Liu Y, Li X, Zhang Q, Xu X, Gu Y, Zhang Y, Zhao D, Cao X. The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation. Nat Immunol. 2016; 17(10):1167-1175. [PubMed]
7. Liu Y, Cao X. Organotropic metastasis: role of tumor exosomes. Cell Res. 2016; 26(2):149-150. [PubMed]
8. Wang W, Jiang M, Liu S, Zhang S, Liu W, Ma Y, Zhang L, Zhang J, Cao X. RNF122 suppresses antiviral type I interferon production by targeting RIG-I CARDs to mediate RIG-I degradation. Proc Natl Acad Sci U S A. 2016; 113(34):9581-9586. [PubMed]
9. Yu Z, Chen T, Li X, Yang M, Tang S, Zhu X, Gu Y, Su X, Xia M, Li W, Zhang X, Wang Q, Cao X, Wang J. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Elife. 2016; 5. pii: e14087. doi:10.7554/eLife.14087. [PubMed]
10. Zhao D, Zhang Q, Liu Y, Li X, Zhao K, Ding Y, Li Z, Shen Q, Wang C, Li N, Cao X. H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1. Cell Rep. 2016; 15(2):288-299. [PubMed]
11. Gao Q, Zhang Y, Han C, Hu X, Zhang H, Xu X, Tian J, Liu Y, Ding Y, Liu J, Wang C, Guo Z, Yang Y, Cao X. Blockade of CD47 ameliorates autoimmune inflammation in CNS by suppressing IL-1-triggered infiltration of pathogenic Th17 cells. J Autoimmun. 2016; 69:74-85. [PubMed]
12. Meng J, Liu X, Zhang P, Li D, Xu S, Zhou Q, Guo M, Huai W, Chen X, Wang Q, Li N, Cao X. Rb selectively inhibits innate IFN-β production by enhancing deacetylation of IFN-β promoter through HDAC1 and HDAC8. J Autoimmun. 2016; 73:42-53. [PubMed]
13. Li X, Yang M, Yu Z, Tang S, Wang L, Cao X, Chen T. The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection. Sci Signal. 2017; 10(460). [PubMed]
14. Hu X, Han C, Jin J, Qin K, Zhang H, Li T, Li N, Cao X. Integrin CD11b attenuates colitis by strengthening Src-Akt pathway to polarize anti-inflammatory IL-10 expression. Sci Rep. 2016; 6:26252. [PubMed]
15. Ren W, Wang C, Wang Q, Zhao D, Zhao K, Sun D, Liu X, Han C, Hou J, Li X, Zhang Q, Cao X, Li N. Bromodomain protein Brd3 promotes Ifnb1 transcription via enhancing IRF3/p300 complex formation and recruitment to Ifnb1 promoter in macrophages. Sci Rep. 2017; 7:39986. [PubMed]
16. Liu J, Cao X. Cellular and molecular regulation of innate inflammatory responses. Cell Mol Immunol. 2016; 13(6):711-721. [PubMed]
17. Zhao K, Zhang Q, Li X, Zhao D, Liu Y, Shen Q, Yang M, Wang C, Li N, Cao X. Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I. J Immunol. 2016; 196(3):1209-1217. [PubMed]
18. Zheng Q, Hou J, Zhou Y, Yang Y, Cao X. Type I IFN-Inducible Downregulation of MicroRNA-27a Feedback Inhibits Antiviral Innate Response by Upregulating Siglec1/TRIM27. J Immunol. 2016; 196(3):1317-1326. [PubMed]
19. Liu Y, Cao X. Immunosuppressive cells in tumor immune escape and metastasis. J Mol Med (Berl). 2016; 94(5):509-522. [PubMed]
20. Cao X. Integrative strategy for improving cancer immunotherapy. J Mol Med (Berl). 2016; 94(5):485-487. [PubMed]
21. Yuan M, Zhu H, Xu J, Zheng Y, Cao X, Liu Q. Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils. J Immunol Res. 2016; 2016:6530410. [PubMed]
22. Zhang X, Jiang Z, Gu Y, Liu Y, Cao X, Han Y. Inflammation-induced CD69+ Kupffer cell feedback inhibits T cell proliferation via membrane-bound TGF-β1. Sci China Life Sci. 2016; 59(12):1259-1269. [PubMed]
23. Tian Z, Cao X, Chen Y, Lyu Q. Regional immunity in tissue homeostasis and diseases. Sci China Life Sci. 2016; 59(12):1205-1209. [PubMed]
1. Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, Su X, Liu J, Ge W, Levine RL, Li N, Cao X. Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature. 2015; 525(7569):389-393. [PubMed]
2. Yang M, Chen T, Li X, Tang S, Wang C, Gu Y, Liu Y, Xu S, Li W, Zhang X, Wang J, Cao X. K33-linked polyubiquitination of Zap70 by E3 ligase Nrdp1 controls activation of CD8+ T cells. Nat Immunol. 2015; 16(12):1253-1262. [PubMed]
3. Cao X. A call for global research on non-communicable diseases. Lancet. 2015; 385(9967):e5-6. [PubMed]
4. Zheng Q, Hou J, Zhou Y, Yang Y, Xie B, Cao X. Siglec1 suppresses antiviral innate immune response by inducing TBK1 degradation via the ubiquitin ligase TRIM27. Cell Res. 2015; 25(10):1121-1136. [PubMed]
5. Su X, Wang H, Ge W, Yang M, Hou J, Chen T, Li N, Cao X. An In Vivo Method to Identify microRNA Targets Not Predicted by Computation Algorithms: p21 Targeting by miR-92a in Cancer. Cancer Res. 2015; 75(14):2875-2885. [PubMed]
6. Wang H, Su X, Yang M, Chen T, Hou J, Li N, Cao X. Reciprocal control of miR-197 and IL-6/STAT3 pathway reveals miR-197 as potential therapeutic target for hepatocellular carcinoma. Oncoimmunology. 2015; 4(10):e1031440. [PubMed]
7. Liu Y, Zhang Q, Ding Y, Li X, Zhao D, Zhao K, Guo Z, Cao X. Histone lysine methyltransferase Ezh1 promotes TLR-triggered inflammatory cytokine production by suppressing Tollip. J Immunol. 2015; 194(6):2838-2846. [PubMed]
8. Han Y, Jiang Z, Chen Z, Gu Y, Liu Y, Zhang X, Cao X. Pathogen-expanded CD11b+ invariant NKT cells feedback inhibit T cell proliferation via membrane-bound TGF-β1. J Autoimmun. 2015; 58:21-35. [PubMed]
9. Liu J, Cao X. Regulatory dendritic cells in autoimmunity: A comprehensivereview. J Autoimmun. 2015; 63:1-12. [PubMed]
10. Liu Y, Cao X. Intratumoral dendritic cells in the anti-tumor immune response. Cell Mol Immunol. 2015; 12(4):387-390. [PubMed]
11. Bao Y, Cao X. Epigenetic Control of B Cell Development and B-Cell-Related Immune Disorders. Clin Rev Allergy Immunol. 2016; 50(3):301-311. [PubMed]
12. Yu Z, Chen T, Cao X. Neutrophil sensing of cytoplasmic, pathogenic DNA in a cGAS-STING-independent manner. Cell Mol Immunol. 2016; 13(4):411-414. [PubMed]
13. Zhang Y, Cao X. Long noncoding RNAs in innate immunity. Cell Mol Immunol. 2015; 13(2):138-147. [PubMed]
14. Liu Y, Gu Y, Cao X. The exosomes in tumor immunity. Oncoimmunology. 2015; 4(9):e1027472. [PubMed]
15. Yu Z, Chen T, Cao X. RNA editing by ADAR1 marks dsRNA as "self". Cell Res. 2015; 25(12):1283-1284. [PubMed]
16. Lin X, Rui K, Deng J, Tian J, Wang X, Wang S, Ko KH, Jiao Z, Chan VS, Lau CS, Cao X, Lu L. Th17 cells play a critical role in the development of experimental Sjogren\'s syndrome. Ann Rheum Dis. 2015; 74(6):1302-1310. [PubMed]
17. Ge W, Li D, Gao Y, Cao X. The Roles of Lysosomes in Inflammation and Autoimmune Diseases. Int Rev Immunol. 2015; 34(5):415-431. [PubMed]
18. Zhang P, Liu X, Cao X. Extracellular pattern recognition molecules in health and diseases. Cell Mol Immunol. 2015; 12(3):255-257. [PubMed]
19. Tian J, Zhu T, Liu J, Guo Z, Cao X. Platelets promote allergic asthma through the expression of CD154. Cell Mol Immunol. 2015; 12(6):700-707. [PubMed]
1. Han Y, Chen Z, Yang Y, Jiang Z, Gu Y, Liu Y, Lin C, Pan Z, Yu Y, Jiang M, Zhou W, Cao X. Human CD14+ CTLA-4+ regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma. Hepatology. 2014; 59(2):567-579. [PubMed]
2. Liu Q, Tan Q, Zheng Y, Chen K, Qian C, Li N, Wang Q, Cao X. Blockade of Fas signaling in breast cancer cells suppresses tumor growth and metastasis via disruption of Fas signaling-initiated cancer-related inflammation. J Biol Chem. 2014; 289(16):11522-11535. [PubMed]
3. Han Y, Yang Y, Chen Z, Jiang Z, Gu Y, Liu Y, Xu S, Lin C, Pan Z, Zhou W, Cao X. Human hepatocellular carcinoma-infiltrating CD4⁺CD69⁺Foxp3⁻ regulatory T cell suppresses T cell response via membrane-bound TGF-β1. J Mol Med (Berl). 2014; 92(5):539-550. [PubMed]
4. Qian C, Liu J, Cao X. Innate signaling in the inflammatory immune disorders. Cytokine Growth Factor Rev. 2014; 25(6):731-738. [PubMed]
5. Meng J, Liu X, Cao X. A new cytosolic DNA-recognition pathway for DNA-induced inflammatory responses. Cell Mol Immunol. 2014; 11(6):506-509. [PubMed]
6. Wu C, Xue Y, Wang P, Lin L, Liu Q, Li N, Xu J, Cao X. IFN-γ primes macrophage activation by increasing phosphatase and tensin homolog via downregulation of miR-3473b. J Immunol. 2014; 193(6):3036-3044. [PubMed]
7. Tang S, Chen T, Yu Z, Zhu X, Yang M, Xie B, Li N, Cao X, Wang J. RasGRP3 limits Toll-like receptor-triggered inflammatory response in macrophages by activating Rap1 small GTPase. Nat Commun. 2014; 5:4657. [PubMed]
8. Wang P, Du H, Zhou CC, Song J, Liu X, Cao X, Mehta JL, Shi Y, Su DF, Miao CY. Intracellular NAMPT-NAD+-SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors. Cardiovasc Res. 2014; 104(3):477-488. [PubMed]
9. Wang D, Zheng M, Qiu Y, Guo C, Ji J, Lei L, Zhang X, Liang J, Lou J, Huang W, Dong B, Wu S, Wang J, Ke Y, Cao X, Zhou YT, Lu L. Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. J Exp Med. 2014; 211(13):2635-2649. [PubMed]
10. Cao X. Innovating research in China. Science. 2014; 346(6213):1035. [PubMed]
11. He Q, Zhang H, Wang Y, Ting HH, Yu W, Cao X, Ge W. Purified anti-CD3 × anti-HER2 bispecific antibody potentiates cytokine-induced killer cells of poor spontaneous cytotoxicity against breast cancer cells. Cell Biosci. 2014; 4(1):70. [PubMed]
12. Fang H, Ang B, Xu X, Huang X, Wu Y, Sun Y, Wang W, Li N, Cao X, Wan T. TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells. Cell Mol Immunol. 2014; 11(2):150-159. [PubMed]
13. Gu M, Ouyang C, Lin W, Zhang T, Cao X, Xia Z, Wang X. Phosphatase holoenzyme PP1/GADD34 negatively regulates TLR response by inhibiting TAK1 serine 412 phosphorylation. J Immunol. 2014; 192(6):2846-2856. [PubMed]
14. Bao Y, Liu X, Han C, Xu S, Xie B, Zhang Q, Gu Y, Hou J, Qian L, Qian C, Han H, Cao X. Identification of IFN-γ-producing innate B cells. Cell Res. 2014; 24(2):161-176. [PubMed]
15. Bao Y, Cao X. The immune potential and immunopathology of cytokine-producing B cell subsets: A comprehensive review. J Autoimmun. 2014; 55:10-23. [PubMed]
16. Jiang Z, Han Y, Cao X. Induced pluripotent stem cell (iPSCs) and their application in immunotherapy. Cell Mol Immunol. 2014; 11(1):17-24. [PubMed]
17. Yao Z, Zhang Q, Li X, Zhao D, Liu Y, Zhao K, Liu Y, Wang C, Jiang M, Li N, Cao X. Death domain-associated protein 6 (Daxx) selectively represses IL-6 transcription through histone deacetylase 1 (HDAC1)-mediated histone deacetylation in macrophages. J Biol Chem. 2014; 289(13):9372-9379. [PubMed]
18. Chen T, Yang M, Yu Z, Tang S, Wang C, Zhu X, Guo J, Li N, Zhang W, Hou J, Liu H, Han C, Liu Q, Gu Y, Qian C, Wan T, Cui L, Zhu M, Zheng W, Cao X. Small GTPase RBJ Mediates Nuclear Entrapment of MEK1/MEK2 in Tumor Progression. Cancer Cell. 2014; 25(5):682-696. [PubMed]
19. Hou J, Zhou Y, Zheng Y, Fan J, Zhou W, Ng IO, Sun H, Qin L, Qiu S, Lee JM, Lo CM, Man K, Yang Y, Yang Y, Yang Y, Zhang Q, Zhu X, Li N, Wang Z, Ding G, Zhuang SM, Zheng L, Luo X, Xie Y, Liang A, Wang Z, Zhang M, Xia Q, Liang T, Yu Y, Cao X. Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma. Cancer Cell. 2014; 25(1):49-63. [PubMed]
20. Wang P, Xue Y, Han Y, Lin L, Wu C, Xu S, Jiang Z, Xu J, Liu Q, Cao X. The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation. Science. 2014; 344(6181):310-313. [PubMed]
21. Liu J, Han C, Xie B, Wu Y, Liu S, Chen K, Xia M, Zhang Y, Song L, Li Z, Zhang T, Ma F, Wang Q, Wang J, Deng K, Zhuang Y, Wu X, Yu Y, Xu T, Cao X. Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. Nat Immunol. 2014; 15(7):612-622. [PubMed]
1. Chen W, Han C, Xie B, Hu X, Yu Q, Shi L, Wang Q, Li D, Wang J, Zheng P, Liu Y, Cao X. Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell. 2013; 152(3):467-478. [PubMed]
2. Xia M, Liu J, Wu X, Liu S, Li G, Han C, Song L, Li Z, Wang Q, Wang J, Xu T, Cao X. Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20. Immunity. 2013; 39(3):470-481. [PubMed]
3. Jin J, Yu Q, Han C, Hu X, Xu S,Wang Q, Wang J, Li N, Cao X. LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition. Nat Commun. 2013; 4:2075. [PubMed]
4. Su X, Qian C, Zhang Q, Hou J, Gu Y, Han Y, Chen Y, Jiang M, Cao X. miRNomes of haematopoietic stem cells and dendritic cells identify miR-30b as a regulator of Notch1. Nat Commun. 2013; 4:2903. [PubMed]
5. Liu J, Liu S, Xia M, Xu S, Wang C, Bao Y, Jiang M, Wu Y, Xu T, Cao X. Rhomboid domain-containing protein 3 is a negative regulator of TLR3-triggered natural killer cell activation. Proc Natl Acad Sci USA. 2013; 110(19):7814-7819. [PubMed]
6. Liu X, Zhang P, Bao Y, Han Y, Wang Y, Zhang Q, Zhan Z, Meng J, Li Y, Li N, Zhang WJ, Cao X. Zinc finger protein ZBTB20 promotes toll-like receptor-triggered innate immune responses by repressing IκBα gene transcription. Proc Natl Acad Sci USA. 2013; 110(27):11097-11102. [PubMed]
7. Zhang P, Liu X, Li Y, Zhu X, Zhan Z, Meng J, Li N, Cao X. Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase β/NF-κB activation. J Immunol. 2013; 190(4):1685-1694. [PubMed]
8. Chen Z, Han Y, Gu Y, Liu Y, Jiang Z, Zhang M, Cao X. CD11c(high)CD8+ regulatory T cell feedback inhibits CD4 T cell immune response via Fas ligand-Fas pathway. J Immunol. 2013; 190(12):6145-6154. [PubMed]
9. Lin L, Hou J, Ma F, Wang P, Liu X, Li N, Wang J, Wang Q, Cao X. Type I IFN Inhibits Innate IL-10 Production in Macrophages through Histone Deacetylase 11 by Downregulating MicroRNA-145. J Immunol. 2013; 191(7):3896-3904. [PubMed]
10. Li Y, Zhang P, Wang C, Han C, Meng J, Liu X, Xu S, Li N, Wang Q, Shi X, Cao X. Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species. J Biol Chem. 2013; 288(23):16225-16234. [PubMed]
11. Wang C, Liu X, Liu Y, Zhang Q, Yao Z, Huang B, Zhang P, Li N, Cao X. ZFP64 promotes TLR-triggered pro-inflammatory and type I interferon production in macrophages by enhancing p65 activation. J Biol Chem. 2013; 288(34):24600-24608. [PubMed]
12. Qian C, Qian L, Yu Y, An H, Guo Z, Han Y, Chen Y, Bai Y, Wang Q, Cao X. Fas signal promotes the immunosuppressive function of regulatory dendritic cells via ERK/β-catenin pathway. J Biol Chem. 2013; 288(39):27825-27835. [PubMed]
1. Xu S, Liu X, Bao Y, Zhu X, Han C, Zhang P, Zhang X, Li W, Cao X. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol. 2012; 13(6):551-559. [PubMed]
2. Qian L, Qian C, Chen Y, Bai Y, Bao Y, Lu L, Cao X. Regulatory dendritic cells program B cells to differentiate into CD19hiFcγIIbhi regulatory B cells through IFN-β and CD40L. Blood. 2012; 120(3):581-591. [PubMed]
3. Xu X, Yi H, Guo Z, Qian C, Xia S, Yao Y, Cao X. Splenic stroma-educated regulatory dendritic cells induce apoptosis of activated CD4 T cells via Fas ligand-enhanced IFN-γ and nitric oxide. J Immunol. 2012; 188(3):1168-1177. [PubMed]
4. Bai Y, Qian C, Qian L, Ma F, Hou J, Chen Y, Wang Q, Cao X. Integrin CD11b negatively regulates TLR9-triggered dendritic cell cross-priming by upregulating microRNA-146a. J Immunol. 2012; 188(11):5293-5302. [PubMed]
5. Wang P, Gu Y, Zhang Q, Han Y, Hou J, Lin L, Wu C, Bao Y, Su X, Jiang M, Wang Q, Li N, Cao X. Identification of resting and type I IFN-activated human NK cell miRNomes reveals microRNA-378 and microRNA-30e as negative regulators of NK cell cytotoxicity. J Immunol. 2012; 189(1):211-221. [PubMed]
6. Bao Y, Zheng J, Han C, Jin J, Han H, Liu Y, Lau YL, Tu W, Cao X. Tyrosine kinase Btk is required for NK cell activation. J Biol Chem. 2012; 287(28):23769-23778. [PubMed]
7. Ye S, Xu H, Jin J, Yang M, Wang C, Yu Y, Cao X. The E3 ubiquitin ligase neuregulin receptor degradation protein 1 (Nrdp1) promotes M2 macrophage polarization by ubiquitinating and activating transcription factor CCAAT/enhancer-binding Protein β (C/EBPβ). J Biol Chem. 2012; 287(32):26740-26748. [PubMed]
8. Qian C, Cao X. Naturally occurring CD1c+ human regulatory dendritic cells: immunoregulators that are expanded in response to E. coli infection. Eur J Immunol. 2012; 42(6):1388-1392. [PubMed]
9. Wang D, Zheng M, Lei L, Ji J, Yao Y, Qiu Y, Ma L, Lou J, Ouyang C, Zhang X, He Y, Chi J, Wang L, Kuang Y, Wang J, Cao X, Lu L. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol. 2012; 13(6):560-568. [PubMed]
10. Yan D, Wang X, Luo L, Cao X, Ge B. Inhibition of TLR signaling by a bacterial protein containing immunoreceptor tyrosine-based inhibitory motifs. Nat Immunol. 2012; 13(11):1063-1071. [PubMed]
11. Deng J, Liu Y, Yang M, Wang S, Zhang M, Wang X, Ko KH, Hua Z, Sun L, Cao X, Lu L. Leptin exacerbates collagen-induced arthritis via enhancement of Th17 cell response. Arthritis Rheum. 2012; 64(11):3564-3573. [PubMed]
12. Liu Y, Lai L, Chen Q, Song Y, Xu S, Ma F, Wang X, Wang J, Yu H, Cao X, Wang Q. MicroRNA-494 is required for the accumulation and functions of tumor-expanded myeloid-derived suppressor cells via targeting of PTEN. J Immunol. 2012; 188(11):5500-5510. [PubMed]
13. Cai Z, Yang F, Yu L, Yu Z, Jiang L, Wang Q, Yang Y, Wang L, Cao X, Wang J. Activated T cell exosomes promote tumor invasion via Fas signaling pathway. J Immunol. 2012; 188(12):5954-5961. [PubMed]
14. Yang M, Deng J, Liu Y, Ko KH, Wang X, Jiao Z, Wang S, Hua Z, Sun L, Srivastava G, Lau CS, Cao X, Lu L. IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation. Am J Pathol. 2012; 180(6):2375-2385. [PubMed]
15. Li Y, Zhao LD, Tong LS, Qian SN, Ren Y, Zhang L, Ding X, Chen Y, Wang YX, Zhang W, Zeng XF, Zhang FC, Tang FL, Zhang X, Ba DN, He W, Cao XT, Lipsky PE. Aberrant CD200/CD200R1 expression and function in systemic lupus erythematosus contributes to abnormal T-cell responsiveness and dendritic cell activity. Arthritis Res Ther. 2012; 14(3):R123. [PubMed]
16. Chen Q, Wang H, Liu Y, Song Y, Lai L, Han Q, Cao X, Wang Q. Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1β production in macrophages by targeting STAT3. PLoS One. 2012; 7(8):e42971. [PubMed]
1. Liu X, Zhan Z, Li D, Xu L, Ma F, Zhang P, Yao H, Cao X. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol. 2011; 12(5):416-424. [PubMed]
2. Ma F, Xu S, Liu X, Zhang Q, Xu X, Liu M, Hua M, Li N, Yao H, Cao X. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. Nat Immunol. 2011; 12(9):861-869. [PubMed]
3. Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, Tian W, Zhang Q, Wang C, Zhang Q, Zhuang SM, Zheng L, Liang A, Tao W, Cao X. Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as therapeutic target for hepatocellular carcinoma. Cancer Cell. 2011; 19(2):232-243. [PubMed]
4. Zhang M, Xu S, Han Y, Cao X. Apoptotic cells attenuate fulminant hepatitis by priming Kupffer cells to produce interleukin-10 through membrane-bound TGF-β. Hepatology. 2011; 53(1):306-316. [PubMed]
5. Xu X, Guo Z, Jiang X, Yao Y, Gao Q, Ding Y, Cao X. Regulatory dendritic cells program generation of interleukin-4-producing alternative memory CD4 T cells with suppressive activity. Blood. 2011; 117(4):1218-1227. [PubMed]
6. Chen T, Guo J, Yang M, Zhu X, Cao X. Chemokine-containing exosomes are released from heat-stressed tumor cells via lipid raft-dependent pathway and act as efficient tumor vaccine. J Immunol. 2011; 186(4):2219-2228. [PubMed]
7. Wu Y, Zhu X, Li N, Chen T, Yang M, Yao M, Liu X, Jin B, Wang X, Cao X. CMRF-35-like molecule 3 preferentially promotes TLR9-triggered proinflammatory cytokine production in macrophages by enhancing TNF receptor-associated factor 6 ubiquitination. J Immunol. 2011; 187(9):4881-4889. [PubMed]
8. Li D, Liu X, Lin L, Hou J, Li N, Wang C, Wang P, Zhang Q, Zhang P, Zhou W, Wang Z, Ding G, Zhuang SM, Zheng L, Tao W, Cao X. MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem. 2011; 286(42):36677-36685. [PubMed]
9. Li D, Liu X, Lin L, Hou J, Li N, Wang C, Wang P, Zhang Q, Zhang P, Zhou W, Wang Z, Ding G, Zhuang SM, Zheng L, Tao W, Cao X. MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma. J Biol Chem. 2011; 286(42):36677-36685. [PubMed]
10. Bao Y, Han Y, Chen Z, Xu S, Cao X. IFN-α-producing PDCA-1+ Siglec-H- B cells mediate innate immune defense by activating NK cells. Eur J Immunol. 2011; 41(3):657-668. [PubMed]
11. Zhang Y, Liu S, Yu Y, Zhang T, Liu J, Shen Q, Cao X. Immune complex enhances tolerogenecity of immature dendritic cells via FcγRIIb and promotes FcγRIIb-overexpressing dendritic cells to attenuate lupus. Eur J Immunol. 2011; 41(4):1154-1164. [PubMed]
12. Bao Y, Cao X. Revisiting the protective and pathogenic roles of neutrophils: Ly-6G is key! Eur J Immunol. 2011; 41(9):2535-2538. [PubMed]
13. Fu Q, Wu Y, Yan F, Wang N, Wang W, Cao X, Wang Y, Wan T. Efficient induction of a Her2-specific anti-tumor response by dendritic cells pulsed with a Hsp70L1-Her2(341-456) fusion protein. Cell Mol Immunol. 2011; 8(5):424-432. [PubMed]
14. Xiao L, Fu ZR, Liu F, Zhang LD, Shi XM, Shen XY, Ni ZJ, Fu H, Li RD, Cao XT, Ding GS, Wang QX. Suppression of allograft rejection by Tim-1-Fc through cross-linking with a novel Tim-1 binding partner on T cells. PLoS One. 2011;6(7):e21697. [PubMed]
15. Liu Y, Chen Q, Song Y, Lai L, Wang J, Yu H, Cao X, Wang Q. MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett. 2011; 585(12):1963-1968. [PubMed]
16. He D, Chen T, Yang M, Zhu X, Wang C, Cao X, Cai Z. Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association. J Mol Med (Berl). 2011; 89(2):137-150. [PubMed]
1. Cai Z, Zhang W, Li M, Yue Y, Yang F, Yu L, Cao X, Wang J. TGF-beta1 gene-modified, immature dendritic cells delay the development of inflammatory bowel disease by inducing CD4(+)Foxp3(+) regulatory T cells. Cell Mol Immunol. 2010; 7(1):35-43. [PubMed]
2. Wang D, Lou J, Ouyang C, Chen W, Liu Y, Liu X, Cao X, Wang J, Lu L. Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Proc Natl Acad Sci U S A. 2010; 107(31):13806-13811. [PubMed]
3. Yang M, Sun L, Wang S, Ko KH, Xu H, Zheng BJ, Cao X, Lu L. Novel Function of B Cell-Activating Factor in the Induction of IL-10–Producing Regulatory B Cells. J Immunol. 2010; 184(7):3321-3325. [PubMed]
4. Han C, Jin J, Xu S, Liu H, Li N, Cao X. Integrin CD11b negatively regulates TLR-triggered inflammatory response by activating Syk and promoting MyD88 and TRIF degradation via cbl-b. Nat Immunol. 2010; 11(8):734-742. [PubMed]
5. Yang P, An H, Liu X, Wen M, Zheng Y, Rui Y, Cao X. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol. 2010; 11(6):487-494. [PubMed]
6. Liu X, Zahn Z, Xu L, Ma F, LiD, Guo Z, Li N, Cao X. MicroRNA-148/152 impair innate response and antigen presentation of TLR-triggered dendritic cells by targeting CaMKIIα. J Immunol. 2010; 185(12):7244-7251. [PubMed]
7. Wang P, Hou J, Lin L, Wang C, Liu X, Li D, Ma F, Wang Z, Cao X. Inducible microRNA-155 feedback promotes type I interferon signaling in antiviral innate immunity by targeting SOCS1. J Immunol. 2010; 185(10):6226-6233. [PubMed]
8. Liu H, Qiu J, Li N, Chen T, Cao X. Human phosphatidylethanolamine-binding protein 4 promotes transactivation of estrogen receptor alpha(ERalpha) in human cancer cells by inhibiting proteasome-dependent ERalpha degradation via association with Src. J Biol Chem. 2010; 285(29):21934-21942. [PubMed]
9. Chen T, Cao X. Stress for maintaining memory: HSP70 as mobile messenger for innate immunity and adaptive immunity. Eur J Immunol. 2010; 40(6):1541-1544. [PubMed]
10. Qiu J, Xiao J, Han C, Li N, Shen X, Jiang H, Cao X. Potentiation of tumor necrosis factor-alpha-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4. J Biol Chem. 2010; 285(16):12241-12247. [PubMed]
11. Xu S, Han Y, Xu X, Bao Y, Zhang M, Cao X. IL-17A-producing γδT cells promote CTL responses against L.monocytogenes infection by enhancing dendritic cell cross-presentation. J Immunol. 2010; 185(10):5879-5887. [PubMed]
12. Ma F, Liu X, Li D, Wang P, Li N, Lu L, Cao X. MicroRNA-466l Upregulates IL-10 Expression in TLR-Triggered Macrophages by Antagonizing RNA-Binding Protein Tristetraprolin-Mediated IL-10 mRNA Degradation. J Immunol. 2010; 184(11):6053-6094. [PubMed]
13. Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X. Scaffolding Adaptor Protein Gab1 Is Required for TLR3/4- and RIG-I-Mediated Production of Proinflammatory Cytokines and Type I IFN in Macrophages. J Immunol. 2010; 184(11):6447-6456. [PubMed]
1. Hong X, Liu Y, Hu G, Zhao D, Shen J, Shen F, Cao X, Wang Q. EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma. Cancer Sci. 2009; 100(5):961-969. [PubMed]
2. Liu G, Liu S, Li P, Tang L, Han Y, An H, Li J, Dai X, Li N, Cao X, Yu Y. Cloning and characterization of DULP, a novel ubiquitin-like molecule from human dendritic cells.. Cell Mol Immunol 2009; 6(1):27-33. [PubMed]
3. Cao X. New DNA sensing pathway feeds RIG-I with RNA. Nat Immunol. 2009; 10(10):149-151. [PubMed]
4. Wang C, Chen T, Zhang J, Yang M, Li N, Xu X, Cao X. The E3 ubiquitin ligase Nrdp1 preferentially promotes TLR-mediated type I interferon production. Nat Immunol. 2009; 10(7):744-752. [PubMed]
5. Zhang M, Han Y, Han C, Xu S, Bao Y, Chen Z, Gu Y, Xia D, and Cao X. Beta2 integrin CD11b attenuates Poly I:C-induced hepatitis via negatively regulating NK cell functions. Hepatology. 2009; 50(5):1606-1616. [PubMed]
6. Zhang T, Liu S, Yang P, Han C, Liu J, Han Y, Wang Q, Yu Y and Cao X. Fibronectin maintains survival of mouse NK cells via CD11b/Src/β-catenin pathway. Blood. 2009; 114(19):4081-4088. [PubMed]
7. Hou J, Wang P, Lin L, Liu X, Ma F, An H, Wang Z, Cao X. MicroRNA-146a feedback inhibits RIG-I-dependent type I IFN production in macrophages by targeting TRAF6, IRAK1 and IRAK2. J Immunol. 2009; 183(3):2150-2158. [PubMed]
8. Yao M, Liu X, Li D, Chen T, Cai Z, Cao X. Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I interferon production in macrophages. J Immunol. 2009; 183(3):1751-1758. [PubMed]
9. Liu Q, Zhang C, Sun A, Zheng Y, Wang L, Cao X. Tumor-educated CD11bhiIalo regulatory dendritic cells suppress T cell response through arginase I. J Immunol. 2009; 182(10):6207-6216. [PubMed]
10. Zhang Y, Liu Q, Zhang M, Yu Y, Liu X and Cao X. Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2. J Immunol. 2009; 182(6):3801-3808. [PubMed]
11. Chen T, Guo J, Han C, Yang M and Cao X. HSP70, released from heat stressed tumor cells, initiates antitumor immunity by inducing tumor cell chemokine production and activating dendritic cells via TLR4 pathway. J Immunol. 2009; 182(3):1449-1459. [PubMed]
12. Han C, Chen T, Yang M, Liu H and Cao X. Human SCAMP5, a novel secretory carrier membrane protein, fascilitates calcium-triggered cytokine secretion by interaction with SNARE machinery. J Immunol. 2009; 182(5):2986-2996. [PubMed]
13. Zhang Y, Liu S, Liu J, Zhang T, Shen Q, Yu Y, Cao X. Immune complex/Ig negatively regulate TLR4-triggered inflammatory response in macrophages through Fc gamma RIIb-dependent PGE2 production. J Immunol. 2009; 182(1):554-562. [PubMed]
14. Li H, Han Y, Guo Q, Zhang M, Cao X. Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound transforming growth factor-β1. J Immunol. 2009; 182(1):240-249. [PubMed]
15. Han Y, Guo Q, Zhang M, Chen Z, Cao X. CD69+CD4+CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-β1. J Immunol. 2009; 182(1):111-120. [PubMed]
16. Ma S, Yang Y, Wang C, Hui N, Gu L, Zhong H, Cai Z, Wang Q, Zhang Q, Li N, and Cao X. Endogenous human CaMKII inhibitory protein suppresses tumor growth by inducing cell cycle arrest and apoptosis through downregulation of PI3K/Akt/HDM2 pathway. J Biol Chem. 2009; 284(37):24773-24782. [PubMed]
17. Wang CM, Chen T, Zhang N, Yang M, Li B, Lu X, Cao X and Ling C. Melittin, A Major Component of Bee Venom, Sensitizes Human Hepatocellular Carcinoma Cells to TRAIL-induced Apoptosis by Activating CaMKⅡ-TAK1-JNK/p38 and Inhibiting IKK-NFκB. J Biol Chem. 2009; 284(6):3804-3813. [PubMed]
18. Wang C, Qi R, Li N, An H, Zhang Q, Yu Y, and Cao X. Notch1 signaling sensitizes TRAIL-induced apoptosis in human hepatocellular carcinoma cells by inhibiting Akt/Hdm2-mediated p53 degradation and up-regulating p53-dependent DR5 expression. J Biol Chem. 2009; 284(24):16183-16190. [PubMed]
19. Li N, Wang CM, Wu Y, Liu X, Cao X. CaMKII promotes cell cycle progression by directly activating MEK1 and subsequently modulating p27 phosphorylation. J Biol Chem. 2009; 284(5):3021-3027. [PubMed]
1. Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci USA. 2008; 105(31):10859-10864. [PubMed]
2. Cao X. Immunology in China: the past, present and future. Nat Immunol. 2008; 9(4):339-342. [PubMed]
3. An H, Hou J, Zhou J, Zhao Y, Xu H, Zheng Y, Yu Y, Liu S and Cao X. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting kinase IRAK-1. Nat Immunol. 2008; 9(5):542-550. [PubMed]
4. Liu X, Yao M, Li N, Wang C, Zheng Y, Cao X. CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood. 2008; 112(13):4961-4970. [PubMed]
5. Xia S, Guo Z, Xu X, Yi H and Cao X. Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells maintaining liver tolerance. Blood. 2008; 112(8):3175-3185. [PubMed]
6. Wang C, Li N, Liu X, Zheng Y and Cao X. A Novel Endogenous Human CaMKII Inhibitory Protein Suppresses Tumor Growth by Inducing Cell Cycle Arrest via p27 Stabilization. J Biol Chem. 2008; 283(17):11565-11574. [PubMed]
7. Li L, Liu S, Zhang T, Pan W, Yang X, Cao X. Splenic stromal microenvironment negatively regulates virus-activated plasmacytoid dendritic cells through TGF-β. J Immunol. 2008; 180(5):2951-2956. [PubMed]
8. Li Q, Guo Z, Xu X, Xia S, and Cao X. Pulmonary stromal cells induce generation of regulatory dendritic cells attenuating T cell-mediated lung inflammation. Eur J Immunol. 2008; 38(10):2751-2761. [PubMed]
9. Li C, Liu Q, Li N, Chen W, Wang L, Wang Y, Yu Y and Cao X. EAPF/Phafin-2, a novel endoplasmic reticulum-associated protein, facilitates TNF-triggered cellular apoptosis through endoplasmic reticulum-mitochondrial apoptotic pathway. J Mol Med. 2008; 86(4):471-484. [PubMed]
10. Liu S, Wu J, Zhang T, Qian B, Wu P, Li L, Yu Y, Cao X. Complement C1q chemoattracts human dendritic cells and enhances migration of mature dendritic cells to CCL19 via activation of AKT and MAPK pathways. Mol Immunol. 2008; 46(2):242-249. [PubMed]
11. Xu H, An H, Hou J, Han C, Wang P, Yu Y, and Cao X. Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages. Mol Immunol. 2008; 45(13):3545-3552. [PubMed]
12. Xia S, Guo Z, Yao Y, Xu X, Yi H, Xia D, Cao X. Liver stroma enhances activation of TLR3-triggered NK cells through fibronectin. Mol Immunol. 2008; 45(10):2831-2838. [PubMed]
13. Sun Q, Liu Q, Zheng Y and Cao X. Rapamycin suppresses TLR4-triggered IL-6 and PGE2 production of colon cancer cells by inhibiting TLR4 expression and NF-κB activation. Mol Immunol. 2008; 45(10):2929-2936. [PubMed]
14. Jiang Y, Chen G, Zheng Y, Lu L, Wu C, Zhang Y, Liu Q, Cao X. TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-κB pathways. Mol Immunol. 2008; 45(6):1557-1566. [PubMed]
15. Wu P, Wu J, Liu S, Han X, Lu J, Shi Y, Wang J, Lu L and Cao X. TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients. Clin Immunol. 2008; 129(1):40-48. [PubMed]
16. Liu Q, Shu X, Sun A, Sun Q, Zhang C, An H, Liu J, Cao X. Plant-derived small molecule albaconol suppresses LPS-triggered proinflammatory cytokine production and antigen presentation of dendritic cells by impairing NF-kappaB activation. Int Immunopharmacol. 2008; 8(8):1103-1111. [PubMed]
17. Wang L, Liu Q, Sun Q, Zhang C, Chen T, Cao X. TLR4 signaling in cancer cells promotes chemoattraction of immature dendritic cells via autocrine CCL20. Biochem Biophys Res Commun. 2008; 366(3):857-861. [PubMed]
18. Liu X, Zhang Y, Yu Y, Yang X, Cao X. SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-beta1/Smad3 signaling. Mol Immunol. 2008; 45(5):1405-1413. [PubMed]
19. Sun Q, Zheng Y, Liu Q and Cao X. Rapamycin reverses TLR4 signaling-triggered tumor apoptosis resistance by disrupting Akt-mediated Bcl-xL upregulation. Int Immunopharmacol. 2008; 8(13-14):1854-1858. [PubMed]
1. Lam QL, Zheng BJ, Jin DY, Cao X, Lu L. Leptin induces CD40 expression through the activation of Akt in murine dendritic cells. J Biol Chem. 2007; 282(38):27587-27597. [PubMed]
2. Wang Y, Chen T, Han C, He D, Liu H, An H, Cai Z, Cao X. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood. 2007; 110(3):962-971. [PubMed]
3. Qain C, An H, Yu Y, Liu S, Cao X. TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation. Blood. 2007; 109(8):3308-3315. [PubMed]
4. Li H, Wang X, Li N, Qiu J, Zhang Y, Cao X. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. J Biol Chem. 2007; 282(7):4943-4950. [PubMed]
5. Jiang Y, Chen G, Zhang Y, Lu L, Liu S and Cao X. Nerve Growth Factor Promotes TLR4 Signaling-induced Maturation of Human Dendritic Cells in vitro through Inducible p75NTR. J Immunol. 2007; 179(9): 6297-6304. [PubMed]
6. Rui Y, Liu X, Li N, Jiang Y, Chen G, Cao X and J Wang. PECAM-1 ligation negatively regulates TLR4 signaling in macrophages. J Immunol. 2007; 179(11):7344-7351. [PubMed]
7. Li N, Zheng Y, Chen W, Wang C, Liu X, He W, Xu H and Cao X. Adaptor Protein LAPF Recruits Phosphorylated p53 to Lysosomes and Triggers Lysosome destabilization in Apoptosis. Cancer Res, 2007; 67(23): 11176-11185. [PubMed]
8. Xiu F, Cai Z, Yang Y, Wang, X, Wang J, Cao X. Surface anchorage of superantigen SEA promotes induction of specific antitumor immune response by tumor-derived exosomes. J Mol Med, 2007, 85 (5):511-521. [PubMed]
9. He W, Liu Q, Wang L, Chen W, Li N, Cao X. TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol. 2007; 44(11):2850-2859. [PubMed]
10. Liu Q, Chen T, Chen G, Shu X, Sun A, Ma P, Lu L, Cao X. Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-κB pathways. Mol Immunol. 2007; 44 (10):2686-2696. [PubMed]
11. Wang Q, Li N, Wang X, Shen J, Hong X, Yu H, Zhang Y, Wan T, Zhang L, Wang J, Cao X. Membrane protein hMYADM preferentially expressed in myeloid cells is up-regulated during differentiation of stem cells and myeloid leukemia cells. Life Sci. 2007; 80(5):420-429. [PubMed]
12. Zhang Y, Wang X, Xiang Z, Li H, Qiu J, Sun Q, Wan T, Li N, Cao X, Wang J. Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein. Int J Mol Med. 2007; 19(1):55-63. [PubMed]
13. Han C, Chen T, Li N, Yang M, Wan T, Cao X. HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. Biochem Biophys Res Commun. 2007; 353 (2):280-285. [PubMed]
14. Yan X, Xiu F, An H, Wang X, Wang J, Cao X. Fever range temperature promotes TLR4 expression and signaling in dendritic cells. Life Sci. 2007; 80(4):307-313. [PubMed]
15. Yang Y, Xiu F, Cai Z, Wang J, Wang Q, Fu Y, Cao X. Increased induction of antitumor response by exosomes derived from interleukin-2 gene-modified tumor cells. J Cancer Res Clin Oncol. 2007; 133(6):889-899. [PubMed]
16. Zhao W, An H, Zhou J, Xu H, Yu Y and Cao X. Hyperthermia differentially regulates TLR4 and TLR2-mediated innate immune response. Immunol Lett. 2007; 108(2):137-142. [PubMed]
1. Lam QL, Liu S, Cao X, Lu L. Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells. Eur J Immunol. 2006; 36(12):3118-3130. [PubMed]
2. Huang X, Zhang M, Tang H, Ruo C, Cao X. Identification and characterization of DEDDL, a human-specific isoform of DEDD. Gene Expr. 2006; 13(3):141-153. [PubMed]
3. Chang Y, Song A, Gao Y, Shi Y, Lin X, Cao X, Lin D, Hu H. Solution structure of the ubiquitin-associated domain of human BMSC-UbP and its complex with ubiquitin. Protein Sci. 2006; 15(6):1248-1259. [PubMed]
4. An H, Zhao W, Hou J, Zhang Y, Xie Y, Zheng Y, Xu H, Qian C, Zhou J, Yu Y, Liu S, Feng G, Cao X. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity. 2006; 25(6):919-928. [PubMed]
5. Qian C, Jiang X, An H, Yu Y, Guo Z, Liu S, Xu H, Cao X. TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation. Blood. 2006; 108(7):2307-2315. [PubMed]
6. Shi L, Luo K, Xia D, Chen T, Chen G, Jiang Y, Li N, Cao X. DIgR2, dendritic cell-derived immunoglobulin receptor 2, is one representative of a family of IgSF inhibitory receptors and mediates negative regulation of dendritic cell-initiated antigen-specific T-cell responses. Blood. 2006; 108(8):2678-2686. [PubMed]
7. Tang H, Guo Z, Zhang M, Wang J, Chen G, Cao X. Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL- 10. Blood. 2006; 108(4):1189-1197. [PubMed]
8. Wang Q, Liu Y, Wang J, Ding G, Zhang W, Chen G, Zhang M, Zheng S, Cao X. Induction of allo-specific tolerance by immature dendritic cells genetically modified to express soluble TNF receptor. J Immunol. 2006; 177(4):2175-2185. [PubMed]
9. Chen W, Wang J, hao C, Liu S, Yu Y, Wang Q, Cao X. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur J Immunol. 2006; 36(6):1598-1607. [PubMed]
10. Dai S, Zhou X, Wang B, Wang Q, Fu Y, Chen T, Wan T, Yu Y, Cao X. Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8(+) CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells. J Mol Med. 2006; 84(12):1067-1076. [PubMed]
11. Li P, Wang X, Li N, Kong H, Guo Z, Liu S, Cao X. Anti-apoptotic hPEBP4 silencing promotes TRAIL-induced apoptosis of human ovarian cancer cells by activating ERK and JNK pathways. Int J Mol Med. 2006; 18(3):505-510. [PubMed]
12. Sui L, Zhang W, Chen Y, Zheng Y, Wan T, Zhang W, Yang Y, Fang G, Mao J, Cao X. Human membrane protein Tim-3 facilitates hepatitis A virus entry into target cells. Int J Mol Med. 2006; 17(6):1093-1099. [PubMed]
13. Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, Cao X. Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem Biophys Res Commun. 2006; 345(3):1122-1130. [PubMed]
14. Liu X, Li N, Wang C, Zhang X, Zheng Y, Cao X. Molecular Cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells. Life Sci. 2006; 79(19):1828-1838. [PubMed]
1. Gao Y, Song A, Shi Y, Chang Y, Liu S, Yu Y, Cao X, Lin D, Hu H. Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells. Protein Sci. 2005; 14(8):2044-2050. [PubMed]
2. Huang C, Yu H, Wang Q, Yang G, Ma W, Xia D, Chen X, Yi P, Shen F, Zheng H, Cao X. A novel anticancer approach: SEA-anchored tumor cells expressing heat shock protein 70 onto the surface elicit strong anticancer efficacy. Immunol Lett. 2005; 101(1):71-80. [PubMed]
3. An H, Xu H, Zhang M, Zhou J, Feng T, Qian C, Qi R, and Cao X. Src homology domain-containing inositol-5-phosphatase 1 (SHIP1) negatively regulates TLR4-mediated LPS response primarily through phosphatase activity- and PI-3K-independent mechanism. Blood. 2005; 105(12):4685-4692. [PubMed]
4. Guo Z, Zhang M, Tang H, and Cao X. Fas signal links innate and adaptive immunity by promoting dendritic cell secretion of CC and CXC chemokines. Blood. 2005; 106(6):2033-2041. [PubMed]
5. Chen W, Li N, Chen T, Han Y, Li C, Wang Y, He W, Zhang L, Wan T, Cao X. LAPF, representative of a novel family of PH and FYVE domain-containing proteins, induces caspase-independent apoptosis via lysosomal-mitochondrial pathway. J Biol Chem. 2005; 280(49):40985-40995. [PubMed]
6. Wu Y, Wan T, Zhou X, Wang B, Yang F, Li N, Chen G, Dai S, Liu S, Zhang M and Cao X. Hsp70L1 Fusion Protein Enhances Induction of Carcinoembryonic Antigen-specific CD8+ CTL Response by Dendritic Cell Vaccine. Cancer Res. 2005; 65(11):4947-4954. [PubMed]
7. Chen H, Hou J, Jiang X, Ma S, Meng M, Wang B, Zhang M, Zhang M, Tang X, Zhang F, Wan T, Li N, Yu Y, Hu H, Yang R, He W, Wang X, Cao X. Response of Memory CD8+ T Cells to Severe Acute Respiratory Syndrome (SARS) Coronavirus in Recovered SARS Patients and Healthy Individuals. J Immunol. 2005; 175(1):591-598. [PubMed]
8. Wang T, Xia D, Li N, Wang C, Chen T, Wan T, Chen G, Cao X. Bone marrow stromal cell-derived growth inhibitor, BDGI, inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis. J Biol Chem. 2005; 280(6):4374-4382. [PubMed]
9. Dai S, Wan T, Wang B, Zhou X, Xiu F, Chen T, Wu Y and Cao X. More efficient induction of HLA-A*0201-restricted and CEA-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumour cells. Clin Cancer Res. 2005; 11(20):7554-7563. [PubMed]
10. Wang X, Li N, Li H, Liu B, Qiu J, Chen T and Cao X. Silencing of human phosphatidylethanolamine-binding protein 4 sensitizes breast cancer cells to TNFα-induced apoptosis and cell growth arrest. Clin Cancer Res. 2005; 11(20):7545-7553. [PubMed]
11. Zhou J, An H, Xu H, Liu S and Cao X. Heat shock up-regulates expression of TLR2 and TLR4 in human monocytes via p38 signal pathway. Immunology. 2005; 114(4):522-530. [PubMed]
12. Chen W, Wang J, An H, Zhou J, Zhang L, Cao X. Heat shock up-regulates TLR9 expression in human B cells through activation of ERK and NF-κB signal pathways. Immunol Lett. 2005; 98(1):153-159. [PubMed]
13. He X, Wang J, Guo Z, Liu Q, Chen T, Wang X, Cao X. Requirement for ERK activation in sinomenine-induced apoptosis of macrophages. Immunol Lett. 2005; 98(1):91-96. [PubMed]
14. Sun H, Li N, Wang X, Chen T, Shi L, Zhang L, Wang J, Wan T, Cao X. Molecular cloning and characterization of a novel muscle adenylosuccinate synthetase, AdSSL1, from human bone marrow stromal cells. Mol Cell Biochem. 2005; 269(1-2):85-94. [PubMed]
15. Pan J, Zhang M, Wang J, Wang Q, Xia D, Sun W, Zhang L, Yu H, Cao X. Intratumoral injection of interferon-gamma gene-modified dendritic cells elicits potent antitumor effects: effective induction of tumor-specific CD8(+) CTL response. J Cancer Res Clin Oncol. 2005; 131(7):468-478. [PubMed]
1. Huang C, Yu H, Wang Q, Ma W, Xia D, Yi P, Zhang L, Cao X. Potent antitumor effect elicited by superantigen-linked tumor cells transduced with heat shock protein 70 gene. Cancer Sci. 2004; 95(2):160-167. [PubMed]
2. Xiang Y, Sun S, Cai J, Xiang M, Tang G, Cao X. Enhancement of fractionated bone marrow transplantation on hematopoietic cell homing in a mouse allogeneic model. Transplantation. 2004; 77(7):972-978. [PubMed]
3. Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, Guo J, Huang X, Chen T, Wang J, Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nature Immunology. 2004; 5(11):1124-1133. [PubMed]
4. Han Y, Zhang M, Li N, Chen T, Zhang Y, Wan T, Cao X. KLRL1, a novel killer cell lectin-like receptor, inhibits natural killer cell cytotoxicity. Blood. 2004; 104(9):2858-2866. [PubMed]
5. Wang B, Chen H, Jiang X, Zhang M, Wan T, Li N, Zhou X, Wu Y, Yang F, Yu Y, Wang X, Yang R, Cao X. Identification of an HLA-A*0201-restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein. Blood. 2004; 104(1):201-206. [PubMed]
6. Chen T, Guo J, Yang M, Han C, Zhang M, Chen W, Liu Q, Wang J, Cao X. Cyclosporin A impairs dendritic cell migration by regulating chemokine receptor expression and inhibiting cyclooxygenase-2 expression. Blood. 2004; 103(2):413-421. [PubMed]
7. Wan T, Zhou X, Chen G, An H, Chen T, Zhang W, Liu S, Jiang Y, Yang F, Wu Y and Cao X. Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. Blood. 2004; 103(5):1747-1754. [PubMed]
8. Yang L, Li N, Wang C, Yu Y, Yuan L, Zhang M, Cao X. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. J Biol Chem. 2004; 279(12):11639-11648. [PubMed]
9. Wang X, Li N, Liu B, Sun H, Chen T, Li H, Qiu J, Zhang L, Wan T, and Cao X. A novel human phosphatidylethanolamine-binding protein resists TNFa-induced apoptosis by inhibiting MAPK pathway activation and PE externalization. J Biol Chem. 2004; 279(44):45855-45864. [PubMed]
10. Sui L, Li N, Liu Q, Zhang W, Wan T, Wang B, Luo K, Sun H, Cao X. IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes. Biochem Biophys Res Commun. 2004; 319(3):920-928. [PubMed]
11. Zhang M, Wang Q, Liu Y, Sun Y, Ding G, Fu Z, Min Z, Cao X. Effective induction of immune tolerance by portal venous infusion with IL-10 gene-modified immature dendritic cells leading to prolongation of allograft survival. J Mol Med. 2004; 82(4):240-249. [PubMed]
12. Liu Q, Chen T, Chen H, Zhang M, Li N, Lu Z, Ma P, Cao X. Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP Kinase phosphorylation and caspase 3 activation. Biochem Biophys Res Commun. 2004; 319(3):980-986. [PubMed]
13. Yang M, Chen T, Han C, Li N, T Wan, Cao X. Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells. Biochem Biophys Res Commun. 2004 ; 318(3):792-799. [PubMed]
14. Wang B, Li N, Sui L, Wu Y, Wang X, Wang Q, Xia D, Wan T and Cao X. HuBMSC-MCP, a novel member of mitochondrial carrier superfamily, enhances dendritic cell endocytosis. Biochem Biophys Res Commun. 2004; 314(1):292-300. [PubMed]
15. Lin N, Liu S, Li N, Wu P, An H, Yu Y, Wan T, Cao X. A novel human dendritic cell-derived C1r-like serine protease analog inhibits complement-mediated cytotoxicity. Biochem Biophys Res Commun. 2004; 321(2):329-336. [PubMed]
16. Pan J, Zhang M, Wang J, Wang Q, Xia D, Sun W, Zhang L, Yu H, Liu Y, Cao X. Interferon-gamma is an autocrine mediator for dendritic cell maturation. Immunol Lett. 2004; 94(1-2):141-151. [PubMed]
17. Sun W, He X, Guo Z, Wang Q, Li X, Rayner J, Zhang L, Wang J, Cao X. IL-12p40-overexpressing immature dendritic cells induce T cell hyporesponsiveness in vitro but accelerate allograft rejection in vivo: Role of NK cell activation and interferon-gamma production. Immunol Lett. 2004; 94(3):191-199. [PubMed]
1. Liu X, Tian PK, Ju DW, Zhang MH, Yao M, Cao X, Gu JR. Systemic genetic transfer of p21(WAF-1) and GM-CSF utilizing of a novel oligopeptide-based EGF receptor targeting polyplex. Cancer Gene Ther. 2003; 10(7): 529-539. [PubMed]
2. Guo Z, Zhang M, An H, Chen W, Liu S, Guo J, Yu Y, and Cao X. Fas ligation induces IL-1beta-dependent maturation and IL-1beta-independent survival of dendritic cells: different roles of ERK and NF-kappaB signaling pathways. Blood. 2003; 102(13):4441-4447. [PubMed]
3. Xu H, An H, Yu Y, Zhang M, Qi R, and Cao X. Ras participates in CpG ODN signaling through association with TLR9 and promotion of IRAK1/TRAF6 complex formation in macrophages. J Biol Chem. 2003; 278(38): 36334-36340. [PubMed]
4. Qi R, An H, Yu Y, Zhang M, Liu S, Xu H, Guo Z, Cheng T, Cao X. Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res. 2003; 63(23): 8323-8329. [PubMed]
5. Liu S, Yu Y, An H, Li N, Lin N, Wang W, Zhang W, Wan T and Cao X. Cloning and identification of a novel ubiquitin-like protein, BMSC-UbP, from human bone marrow stromal cells. Immunol Lett. 2003; 86(2):169-175. [PubMed]
6. Xia D, Zheng S, Zhang W, He L, Wang Q, Pan J, Zhang L, Wang J and Cao X. Effective induction of therapeutic antitumor immunity by dendritic cells coexpressing interleukin-18 and tumor antigen. J Mol Med. 2003; 81(9):585-596. [PubMed]
7. Sun W, Wang Q, Zhang L, Liu Y, Zhang M, Wang C, Wang J and Cao X. Blockade of CD40 pathway enhances the induction of immune tolerance by immature dendritic cells genetically modified to express cytotoxic T lymphocyte antigen 4 immunoglobulin. Transplantation. 2003; 76(9):1351-1359. [PubMed]
8. Guo J, Chen T, Wang B, Zhang M, An H, Guo Z, Yu Y, Qin Z and Cao X. Chemoattraction, adhesion and activation of natural killer cells are involved in the antitumor immune response induced by fractalkine/CX3CL1. Immunol Lett. 2003; 89(1):1-7. [PubMed]
9. Guo J, Zhang M, Wang B, Yuan Z, Guo Z, Chen T, Yu Y, Qin Z, Cao X. Fractalkine transgene induces T-cell-dependent antitumor immunity through chemoattraction and activation of dendritic cells. Int J Cancer. 2003; 103(2):212-220. [PubMed]
10. Wang Q, Zhang M, Ding G, Liu Y, Sun Y, Wang J, Zhang W, Fu Z and Cao X. Anti-ICAM-1 antibody and CTLA-4Ig synergistically enhance immature dendritic cells to induce donor-specific immune tolerance in vivo. Immunol Lett. 2003; 90(1):33-42. [PubMed]
11. Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, and Cao X. Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells. Biochem Biophys Res Commun. 2003; 304(2):393-398. [PubMed]
12. Zhang J, Zhang W, Zhou D, Chen G, Wan T, Li N, Cao X. Cloning and functional characterization of GNPI2, a novel human homolog of glucosamine-6-phosphate isomerase/oscillin. J Cell Biochem. 2003; 88(5):932-940. [PubMed]
13. Jiang Y, Wan T, Chen G, Xiu F, Xia D, Zhang W, Zhou X and Cao X. DC-CLM, a cadherin-like molecule cloned from human dendritic cells, inhibits growth of breast cancer cells. J Cancer Res Clin Oncol. 2003; 129(1):57-64. [PubMed]
14. Zhang J, Zhang W, Zou D, Chen G, Wan T, Zhang M and Cao X. Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells. J Cancer Res Clin Oncol. 2003; 129(2):76-83. [PubMed]
15. Leng J, Zhang L, Yao H, Cao X. Antitumor effects of interleukin-18 gene-modified hepatocyte cell line on implanted liver carcinoma. Chin Med J (Engl). 2003; 116(10):1475-1479. [PubMed]
16. Sun H, Li N, Wang X, Liu S, Chen T, Zhang L, Wan T and Cao X. Molecular cloning and characterization of a novel cystatin-like molecule, CLM, from human bone marrow stromal cells. Biochem Biophys Res Commun. 2003; 301(1):176-182. [PubMed]
17. Liu S, An H, Li N, Yu Y, Lin N, Wan T, Zhang M, Wang W, and Cao X. Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells. Biochem Biophys Res Commun. 2003; 300(3):800-805. [PubMed]
18. Chen T, Han Y, Yang M, Zhang W, Li N, WanT, Gou J and Cao X. Rab39, a novel Golgi-associated Rab GTPase from human dendritic cells involved in cellular endocytosis. Biochem Biophys Res Commun. 2003; 303(4):1114-1120. [PubMed]
1. An H, Xu H, Yu Y, Zhang M, Qi R, Yan X, Liu S, Wang W, Guo Z, Qin Z, Cao X. Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways. Immunol Lett. 2002; 81(3):165-169. [PubMed]
2. Qin Z, Harders C, Cao X, Huber C, Blankenstein T, Seliger B. Increased Tumorigenicity, but Unchanged Immunogenicity, of Transporter for Antigen Presentation 1-deficient Tumors. Cancer Res. 2002; 62(10):2856-2860. [PubMed]
3. Liu X, Tian P, Yu Y, Yao M, Cao X, Gu J. Enhanced antitumor effect of EGF R-targeted p21WAF-1 and GM-CSF gene transfer in the established murine hepatoma by peritumoral injection. Cancer Gene Ther. 2002; 9(1):100-108. [PubMed]
4. Yu Y, Liu S, Wang W, Song W, Zhang M, Zhang W, Qin Z, Cao X. Involvement of tumor necrosis factor--related apoptosis-inducing ligand in enhanced cytotoxicity of lipopolysaccharide-stimulated dendritic cells to activated T cells. Immunology. 2002; 106(3):308-316. [PubMed]
5. Wang Q, Yu H, Zhang L, Ju D, Pan J, Xia D, Yao H, Zhang W, Wang J, Cao X. Adenovirus-mediated intratumoral lymphotactin gene transfer potentiates the antibody-targeted superantigen therapy of cancer. J Mol Med (Berl). 2002; 80(9):585-594. [PubMed]
6. Sun W, Wang Q, Zhang L, Pan J, Zhang M, Lu G, Yao H, Wang J, Cao X. TGF-1 gene modified immature dendritic cells exhibit enhanced tolerogenicity but induce allograft fibrosis in vivo. J Mol Med (Berl). 2002; 80(8):514-523. [PubMed]
7. Zhang J, Zhang W, Zou D, Chen G, Wan T, Zhang M, Cao X. Cloning and functional characterization of ACAD-9, a novel member of human acyl-CoA dehydrogenase family. Biochem Biophys Res Commun. 2002; 297(4):1033-1042. [PubMed]
8. Wang Y, Wang W, Li N, Cao X. Activation of antigen presenting cells by immunostimulatory plant DNA:a natural resource for potential adjuvant. Vaccine. 2002; 201(21-22):2764-2771. [PubMed]
9. Guo J, Wang B, Zhang M, Chen T, Yu Y, Regulier E, Homann HE, Qin Z, Ju DW, Cao X. Macrophage-derived chemokine gene transfer results in tumor regression in murine lung carcinoma model through efficient induction of antitumor immunity. Gene Ther. 2002; 9(12):793-803. [PubMed]
10. Xia DJ, Zhang WP, Zheng S, Wang J, Pan JP, Wang Q, Zhang LH, Hamada H, Cao X. Lymphotactin cotransfection enhances the therapeutic efficacy of dendritic cells genetically modified with melanoma antigen gp100. Gene Ther. 2002; 9(9):592-601. [PubMed]
11. An H, Yu Y, Zhang M, Xu H, Qi R, Yan X, Liu S, Wang W, Guo Z, Guo J, Qin Z, Cao X. Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells. Immunology. 2002; 106(1): 38-45. [PubMed]
12. Chen X, Tao Q, Yu H, Zhang L, Cao X. Tumor cell membrane-bound heat shock protein 70 elicits antitumor immunity. Immunol Lett. 2002; 84(2):81-86. [PubMed]
13. Yu Y, Tang L, Wang J, Liu S, Wang W, An H, Qi R, Zhang M, Cao X. Psoriatic lesional keratinocytes promote the maturation of human monocyte-derived langerhans cells. Dermatology. 2002; 204(2):94-99. [PubMed]
1. Liu S, Yu Y, Zhang M, Wang W, Cao X. The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells. J Immunol. 2001. 166(9):5407-5415. [PubMed]
2. Ju DW, Tao Q, Lou G, Bai M, He L, Yang Y, Cao X. Interleukin 18 transfection enhances antitumor immunity induced by dendritic cell-tumor cell conjugates. Cancer Res. 2001; 61(9):3735-3740. [PubMed]
3. Li N, Zhang W, Wan T, Zhang J, Chen T, Yu Y, Wang J, Cao X. Cloning and characterization of siglec-10, a novel sialic acid binding member of the Ig superfamily, from human dendritic cells. J Biol Chem. 2001; 276(30):28106-28112. [PubMed]
4. Zhang LH, Pan JP, Yao HP, Sun WJ, Xia DJ, Wang QQ, He L, Wang J, Cao X. Intrasplenic transplantation of IL-18 gene-modified hepatocytes: an effective approach to reverse hepatic fibrosis in schistosomiasis through induction of dominant Th1 response. Gene Ther. 2001; 8(17):1333-1342. [PubMed]
5. Zhang W, Wan T, Li N, Yuan Z, He L, Zhu X, Yu M, Cao X. Genetic approach to insight into the immunobiology of human dendritic cells and identification of CD84-H1, a novel CD84 homologue. Clinical Cancer Research. 2001; 7(3):822s-829s. [PubMed]
6. Wang Q, Zhang W, Ding G, Sun L, Chen G, Cao X. Dendritic cells support hematopoiesis of bone marrow cells. Transplantation. 2001; 72(5):891-899. [PubMed]
7. Zhang W, Mi J, Li N, Sui L, Wan T, Zhang J, Chen T, Cao X. Identification and characterization of DPZF, a novel human BTB/POZ Zinc finger protein sharing homotogy to BCL-6. Biochem Biophys Res Commun. 2001; 281(4):1067-1073. [PubMed]
8. Zhang J, Li N, Yu J, Zhang W, Cao X. Molecular Cloning and Characterization of a Novel Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor from Human Dendritic Cells. Biochem Biophys Res Commun. 2001; 285(2):229-234. [PubMed]
9. Luo K, Zhang W, Sui L, Li N, Zhang M, Ma X, Zhang L, Cao X. DIgR1, a novel membrane receptor of the immunoglobulin gene superfamily, is preferentially expressed by antigen-presenting cells. Biochem Biophys Res Commun. 2001; 287(1):35-41. [PubMed]
10. Wang Q, Yu H, Ju DW, Zhang L, He L, Cao X. Intratumoral IL-18 gene transfer improves therapeutic efficacy of antibody-targeted superantigen in established murine melanoma. Gene Ther. 2001; 8(7):542-550. [PubMed]
11. Zhang W, Wang J, Wang Q, Chen G, Zhang J, Chen T, Wan T, Zhang Y, Cao X. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. Biochem Biophys Res Commun. 2001; 281(4):878-883. [PubMed]
12. Zhang L, Mi J, Yu Y, Yao H, Chen H, Li M, Cao X. IFN-gamma gene therapy by intrasplenic hepatocyte transplantation: a novel strategy for reversing hepatic fibrosis in Schistosoma japonicum-infected mice. Parasite Immunol. 2001; 23(1):11-17. [PubMed]
13. Zhang L, Ju DW, Sun Y, Tao Q, Qian S, Mi J, Hamada H, Cao X. The potent antitumor effects of combined p16 gene and GM-CSF gene therapy through efficient induction of antitumor immunity. J Cancer Res Clin Oncol. 2001; 127(2):101-108. [PubMed]
14. Xie Z, Cao X, Zhang W, Ye X, Yu B. Endocytic routes of exogenous antigen in murine dendritic cells and macrophages. Chinese Medical Journal. 2001; 114(1):93-96. [PubMed]
15. Chen W, Yu Y, Shao C, Zhang M, Wang W, Zhang L, Cao X. Enhancement of antigen-presenting ability of B lymphoma cells by immunostimulatory CpG-oligonucleotides and anti-CD40 antibody. Immunology Letters. 2001; 77(1):17-23. [PubMed]
16. Pan J Ju D, Wang Q, Zhang M, Xia D, Zhang L, Yu H, Cao X. Dexamethasone inhibits the antigen presentation of dendritic cells in MHC class II pathway. Immunology Letters. 2001; 76(3):153-161. [PubMed]
17. Huang X, Yuan Z, Chen G, Zhang M, Zhang W, Yu Y, Cao X. Cloning and characterization of a novel ITIM containing Lectin-like immunoreceptor LLIR and its two transmembrane region deletion variants. Biochem Biophys Res Commun. 2001; 281(1):131-140. [PubMed]
18. Yuan Z, Huang X, Zhang W, Zhang M, Wan T, Cao X. Cloning and characterization of a novel zinc finger protein (MDZF) that is associated with monocytic differentiation of acute promyelocytic leukemia cells. J Cancer Res Clin Oncol. 2001; 127(11)659-667. [PubMed]
19. Wang Q, Yu H, Zhang L, Ju D, Pan J, Xia D, He L, Wang J, Cao X. Vaccination with IL-18 gene-modified, superantigen-coated tumor cells elicits potent antitumor immune response. J Cancer Res Clin Oncol. 2001; 127(12):718-726. [PubMed]
1. Cao X, Zhang W, Wan T, He L, Chen T, Yuan Z, Ma S, Yu Y, Chen G. Molecular cloning and characterization of a novel CXC chemokine macrophage inflammatory protein-2 gamma chemoattractant for human neutrophils and dendritic cells. J Immunol. 2000; 165(5):2588-2595. [PubMed]
2. Ju DW, Tao Q, Cheng DS, Zhang W, Zhang M, Hamada H, Cao X. Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma. Gene Ther. 2000; 7(4):329-338. [PubMed]
3. Lei H, Ju DW, Yu Y, Tao Q, Chen G, Gu S, Hamada H, Cao X. Induction of potent antitumor response by vaccination with tumor lysate-pulsed macrophages engineered to secrete macrophage colony-stimulating factor and interferon-gamma. Gene Ther. 2000; 7(8):707-713. [PubMed]
4. Ju DW, Yang Y, Tao Q, Song WG, He L, Chen G, Gu S, Ting CC, Cao X. Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity. Gene Ther. 2000; 7(19):1672-1679. [PubMed]
5. Cao X, Huang X, Ju DW, Zhang W, Hamada H, Wang J. Enhanced antitumoral effect of adenovirus-mediated cytosine deaminase gene therapy by induction of antigen-presenting cells through stem cell factor/granulocyte-macrophage colony-stimulating factor gene transfer. Cancer Gene Ther. 2000; 7(2):177-186. [PubMed]
6. Zhang W, Chen T, Wan T, He L, Li N, Yuan Z, Cao X. Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways. Biochem Biophys Res Commun. 2000; 274(3):872-879. [PubMed]
7. Li N, Huang X, Zhao Z, Zhang W, Yu Y, Cao X. Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells. Biochem Biophys Res Commun. 2000; 279(2):487-493. [PubMed]
8. Wang Y, Mi J, Cao X. Anti-DNA antibodies exhibit different binding motif preferences for single stranded or double stranded DAN. Immunol Lett. 2000; 73(1):29-34. [PubMed]
9. Li N, Zhang W, Cao X. Identification of human homologue of mouse IFN-induced protein from human dendritic cells. Immunol Lett. 2000; 74(3):221-224. [PubMed]
10. Huang X, Zhao Z, Yuan Z, Zhang M, Zhu X, Chen G, Cao X. Cloning and characterization of a novel deletion mutant of heterogeneous nuclear ribonucleoprotein M4 from human dendritic cells. Sci China C Life Sci. 2000; 43(6):648-654. [PubMed]
11. Wang Q, Cao X, Wang J, Zhang W, Tao Q, Ye T. Macrophage activation of lymphoma-bearing mice by liposome-mediated intraperitoneal IL-2 and IL-6 gene therapy. Chin Med J (Engl). 2000; 113(3):281-285. [PubMed]
1. Qin Z, Richter G, Schuler T, Ibe S, Cao X, Blankenstein T. B cells inhibit induction of T cell-dependent tumor immunity. Nature Medicine. 1998; 4(5):627-630. [PubMed]
2. Wang J, Saffold S, Cao X, Krauss J, Chen W. Eliciting T cell immunity Against poorly immunogenic tumors by immunization with dendritic cell-tumor fusion vaccines. J Immunol. 1998; 161(10):5516-5524. [PubMed]
3. Cao X, Zhang W, Wang J, Zhang M, Huang X, Hamada H, Chen W. Therapy of established tumour with a hybrid cellular vaccine generated by using granulocyte-macrophage colony-stimulating factor genetically modified dendritic cells. Immunology. 1999; 97(4):616-625. [PubMed]
4. Cao X, Li Q,Ju DW, Wang Q, Tao Q, Wang J. Enhanced antitumor effects of bone marrow transplantation in combination with fibroblast-mediated IL-2 and IL-3 gene therapy. Transplantation. 1999; 67(9):1256-1263. [PubMed]
5. Zhang W, He L,Yuan Z, Xie Z,Wang J, Hamada H, Cao X. Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin. Hum Gene Ther. 1999; 10(7):1151-1161. [PubMed]
6. Zhao Z, Huang X, Li N, Zhu X, Chen S, Cao X. Direct cloning of cell differential expression genes with full-length by a new strategy based on the multiple rounds of 'long distance'polymerase chain reaction and magnetic beads mediated subtraction. J Biotechnol. 1999; 73(1):35-41. [PubMed]
7. Cao X, Zhang W, Wan T, Yu Y, Wang J. Enhanced antitumor immune responses of IL-2 gene-modified tumor vaccine by combination with IL-1 and low dose cyclophosphamide. J Exp Clin Cance Res. 1999; 18(2):173-179. [PubMed]
7. Cao X, Zhang W, Wan T, Yu Y, Wang J. Enhanced antitumor immune responses of IL-2 gene-modified tumor vaccine by combination with IL-1 and low dose cyclophosphamide. J Exp Clin Cance Res. 1999; 18(2):173-179. [PubMed]
9. Ju DW, Cao X, Tao Q, Wang B, Wang T, Chen G, Yu Y. Augmentation of antitumor effect of daenovirus-mediated CD suicide gene therapy by cotransfer of interleukin 2 gene in melanoma-bearing mice. Chin Med J (Engl). 1999; 112(2):162-165. [PubMed]
10. Cao X, Ju DW, Tao Q, Wang J, Wan T, Wang BM, Zhang W, Hamada H. Adenovirus-mediated GM-CSF gene and cytosine deaminase gene transfer followed by 5-fluorocytosine administration elicit more potent antitumor response in tumor-bearing mice. Gene Ther. 1998; 5(8):1130-1136. [PubMed]
11. Cao X, Ju D, Cai R, Tao Q, Yu Y, Wang J. Effects of fibroblast-mediated interleukin 3 and interleukin 6 gene therapy on hematopoiesis in mice treated with 5-fluorouracil. J Mol Med (Berl). 1998; 76(11):782-789. [PubMed]
12. Cao X, Zhao Y, Yu Y, Wang Y, Zhang M, Zhang W, Wang J. Granulocyte-macrophage colony-stimulating factor induces the differentiation of murine erythroleukaemia cells into dendritic cells. Immunology. 1998; 95(1):141-147. [PubMed]
13. Cao X, Cai R, Ju DW, Tao Q, Yu Y, Wang J. Accelerated recovery of irradiation-induced bone marrow depression by fibroblast-mediated interleukin 6 gene therapy in combination with bone marrow transplantation in mice. Transplantation. 1998; 65(3):325-331. [PubMed]
14. Cao X, Cai R, Ju DW, Tao Q, Yu Y, Wang J. Augmentation of hematopoiesis by fibroblast-mediated interleukin-6 gene therapy in mice with chemotherapy. J Interferon Cytokine Res. 1998; 18(4):227-233. [PubMed]
15. Cao X, Zhang W, Yu Y, Tao Q, Ye T. Induction of antitumor immunity and treatment of preestablished tumors by interleukin-6-gene-transfected melanoma cells combined with low-dose IL-2. J Cancer Res Clin Oncol. 1995; 121(12):721-728. [PubMed]
16. Cao X, Zhang W, He L, Xie Z, Ma S, Tao Q, Yu Y, Hamada H, Wang J. Lymphotactin gene-modified bone marrow dendritic cells act as more potent adjuvants for peptide delivery to induce specific antitumor immunity. J Immunol. 1998; 161(11):6238-6244. [PubMed]
17. Ju DW, Wang B, Cao X. Adenovirus-mediated combination suicide gene and interleukin 2 gene therapy for the treatment of established tumor and induction of antitumor immunity. J Cancer Res Clin Oncol. 1998; 124(12):683-689. [PubMed]
18. Zhao Y, Cao X. Immune activation of erythroleukemia cells induced by interleukin 12. Science in China (Series C). 1998; 41(3):324-329. [PubMed]
19. Yu Y, Cao X, Lei H, Zhang M, Zhang W, Zhu X, Ye T, Wang J. Therapeutic effect on experimental metastatic tumor-bearing mice by vaccination with GM-CSF gene-modified and tumor antigen-pulsed macrophages. Science in China. 1998; 41(1):107-112. [PubMed]
20. DW Ju, Cao X, Arces B. Intratumoral injection of GM-CSF gene encoded recombinant vaccinia virus elicits potent antitumor response in a murine melanoma model. Cancer Gene Ther. 1997; 4(2):139-144. [PubMed]
21. Wan T, Cao X, Ju DW, Aces B. In vivo gene therapy of murine melanoma mediated by recombinant vaccinia virus encoding human IL-2 gene. Int J Oncol. 1997; 10(4):703-708. [PubMed]
22. Cao X, Wang J, Zhang W, Chen G, Kong X, Tani K. Treatment of human hepatocellular carcinoma by fibroblast-mediated human interferonαgene therapy in combination with adoptive chemoimmunotherapy. J Cancer Res Clin Oncol. 1995; 121(8):457-462. [PubMed]
23. Cao X, Zhang W, Ma S, Zhang M, Wang J, Ye T. Enhanced antitumor effects of tumor antigen-pulsed dendritic cells by their transfection with GM-CSF gene. Science in China. 1997; 40(5):539-545. [PubMed]
24. Zhang W, Cao X, Huang X, Wang J, Tao Q and Ye Tiangxing. In vivo distribution and gene expression of geneticall modified hepatocytes after intrasplenic transplantation. Science in China. 1997; 40(5):554-560. [PubMed]
25. Cao X, Chen G, Zhang W, Yu Y and Ye T. Enhanced efficacy of combination of IL-2 gene and IL-6 gene-transfected tumor cells in the treatment of established metastatic tumors. Gene Ther. 1996; 3(5):421-426. [PubMed]
26. Wang J, Cao X, Zhang W, Ye T, Tani K. Treatment of leukemia with fibroblast-mediated interferon-alpha gene therapy alone or in combination with doxorubicin. Leukemia Res. 1996; 20(5):379-384. [PubMed]
27. DW Ju, Cao X, Arces B. Active specific immunotherapy of pulmonary metastasis with vaccinia melanoma oncolysate prepared from granulocyte/macrophage-colony-stimulating-factor-gene-encoded vaccinia virus. J Cancer Res Clin Oncol. 1996; 122(12):716-722. [PubMed]
28. Cao X, Chen G, He L, Zhang W, Yu Y, Ye T. Chemoattractive effect on the effector vells of the supernatants from melanoma cells transfected with the interleukin-2(IL-2), IL-4 or IL-6 gene. J Cancer Res Clin Oncol. 1998; 124(2):88-92. [PubMed]
29. Cao X, Chen G, He L, Zhang W, Yu Y, Wang J. Involvement of MHC class I molecule and ICAM-1 in the enhancement of adhesion and cytotoxic susceptibility to immune effector cells of tumor cells transfected with the interleukin(IL)-2,IL-4,IL-6 gene. J Cancer Res Clin Oncol. 1997. 123(11-12):602-608. [PubMed]
Immunology is the study of biological systems used to defend the body against microbial pathogen infection and fight cancer. Recognition of the invading pathogens and tumor antigens by the antigen-presenting cells APCs including dendritic cells (DC) will activate APCs and allow these APCs to initiate innate and adaptive immune responses against infection and cancer.
Dr. Xuetao Cao's major research interests are innate immunity and inflammation, tumor immunology and immunotherapy. His group has made contributions to the understanding of innate signaling in immunity and inflammation, identification of cell subsets and new molecules in dendritic cell (DC)-initiated immune response and cancer immunotherapy.
His group has identified and functionally characterized 22 novel molecules from a human dendritic cell (DC) cDNA library since 1998, including HSP70L1, Siglec-10, Septin-10, Cyclin-L2, Nrdp1, Rab7b, hPEBP4 and hCaMKIIN. His group identified several subsets of immune cells with regulatory function, for example, his group found that splenic stroma can drive mature DC to further proliferate and differentiate into IalowCD11bhigh regulatory DC subset which can feedback inhibit immune response. This subset of regulatory DC can also drive generation of new regulatory immune cell subsets including immunosuppressive memory T cells (IL-4hiIL-10hiCD44hiCD62L-CCR7-) and regulatory B cells (IL-10hiCD19hiFcgIIbhi), forming feedback loop for the control of immune response. This led to the hypothesis that the stromal microenvironment physiologically controls immune homeostasis. His group identified miRNomesin DCand also discovered one long-noncoding RNA lnc-DC in human DC differentiation and proposed its new working mode by directly binding cytoplasmic signaling molecule STAT3, adding insight to the epigenetic regulation of immune cell differentiation and function.
His group has identified important mediators and regulators of innate receptor TLR/RIG-I-triggered innate inflammatory response. For example, his group discovered E3 ligase Nrdp1/DRP from human DC cDNA library (1998) and then identified Nrdp1 as the enhancer of type I interferon production. They proposed that Siglec-G, mouse homolog of human Siglec-10 his lab independently cloned from human DC library, can selectively help RNA viruses escape innate immune response by promoting RIG-I degradation. His group showed that membrane MHC-I and intracellular MHC-II molecules can negatively and positively regulate TLR-triggered response. His group showed that Romboid domain-containing protein Rhbdd3 controls autoimmunity and TLR response by suppressing DC production of IL-6 via K27-linked NEMO ubiquitination. His group identified miRNomesin DC and reported several microRNAs as regulators of type I interferon production and function.
In the area of translational research, his group screened and identified several candidates of biomarkers such as microRNA-199 in the predication of cancer patients' prognosis and responsiveness to immunotherapy, and also investigated new approaches to cancer immunotherapy in basic and clinic trial. For example, his group identified hepatic RIG-I as one useful biomarker and tumor suppressor to predict survival and interferon-α therapeutic response in hepatocellular carcinoma patients. His group headed and completed a randomized multi-center Phase II clinical trial of autologous DC-based chemoimmunotherapy of metastatic cancer patients, and exciting therapeutic efficacy has been achieved.
Reviews and Comments
1. Cao X. Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease. Nat Rev Immunol. 2016; 16(1):35-50.
2. Liu J, Qian C, Cao X. Post-translational modification control of innate immunity. Immunity. 2016; 45(1):15-30.
3. Liu Y, Cao X. Characteristics and significance of the pre-metastatic niche. Cancer Cell. 2016; 30(5):668-681.
4. Cao X. Integrative strategy for improving cancer immunotherapy. J Mol Med (Berl). 2016; 94(5):485-487.
5. Cao X. A call for global research on non-communicable diseases. Lancet. 2015; 385(9967):e5-6.
6. Liu Y, Cao X. Organotropic metastasis: role of tumor exosomes. Cell Res. 2015; 26(2):149-150.
7. Liu J, Cao X. Regulatory dendritic cells in autoimmunity: A comprehensive review. J Autoimmun. 2015; 63:1-12.
8. Liu Y, Gu Y, Cao X. The exosomes in tumor immunity. Oncoimmunology. 2015; 4(9):e1027472.
9. Cao X. Innovating research in China. Science. 2014; 346(6213):1035.
Selected Publications
1. Ding Y, Guo Z, Liu Y, Li X, Zhang Q, Xu X, Gu Y, Zhang Y, Zhao D, Cao X. The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I-peptide complex formation. Nat Immunol. 2016; 17(10):1167-1175.
2. Li X, Zhang Q, Ding Y, Liu Y, Zhao D, Zhao K, Shen Q, Liu X, Zhu X, Li N, Cheng Z, Fan G, Wang Q, Cao X. Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity. Nat Immunol. 2016; 17(7):806-815.
3. Liu Y, Gu Y, Han Y, Zhang Q, Jiang Z, Zhang X, Huang B, Xu X, Zheng J, Cao X. Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils. Cancer Cell. 2016; 30(2):243-256.
4. Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, Su X, Liu J, Ge W, Levine RL, Li N, Cao X. Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature. 2015; 525(7569):389-393.
5. Yang M, Chen T, Li X, Tang S, Wang C, Gu Y, Liu Y, Xu S, Li W, Zhang X, Wang J, Cao X. K33-linked polyubiquitination of Zap70 by E3 ligase Nrdp1 controls activation of CD8+ T cells. Nat Immunol. 2015; 16(12):1253-1262.
6. Wang P, Xue Y, Han Y, Lin L, Wu C, Xu S, Jiang Z, Xu J, Liu Q, Cao X. The STAT3-binding long noncoding RNA lnc-DC controls human dendritic cell differentiation.Science. 2014; 344(6181):310-313.
7. Liu J, Han C, Xie B, Wu Y, Liu S, Chen K, Xia M, Zhang Y, Song L, Li Z, Zhang T, Ma F, Wang Q, Wang J, Deng K, Zhuang Y, Wu X, Yu Y, Xu T, Cao X. Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. Nat Immunol. 2014; 15(7):612-622.
8. Hou J, Zhou Y, Zheng Y, Fan J, Zhou W, Ng IO, Sun H, Qin L, Qiu S, Lee JM, Lo CM, Man K, Yang Y, Yang Y, Yang Y, Zhang Q, Zhu X, Li N, Wang Z, Ding G, Zhuang SM, Zheng L, Luo X, Xie Y, Liang A, Wang Z, Zhang M, Xia Q, Liang T, Yu Y, Cao X. Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma. Cancer Cell. 2014; 25(1):49-63. (cover story)
9. Chen T, Yang M, Yu Z, Tang S, Wang C, Zhu X, Guo J, Li N, Zhang W, Hou J, Liu H, Han C, Liu Q, Gu Y, Qian C, Wan T, Cui L, Zhu M, Zheng W, Cao X. Small GTPase RBJ Mediates Nuclear Entrapment of MEK1/MEK2 in Tumor Progression. Cancer Cell. 2014; 25(5):682-696. (cover story)
10. Chen W, Han C, Xie B, Hu X, Yu Q, Shi L, Wang Q, Li D, Wang J, Zheng P, Liu Y, Cao X. Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation. Cell. 2013; 152(3):467-478.
11. Xia M, Liu J, Wu X, Liu S, Li G, Han C, Song L, Li Z, Wang Q, Wang J, Xu T, Cao X. Histone Methyltransferase Ash1l Suppresses Interleukin-6 Production and Inflammatory Autoimmune Diseases by Inducing the Ubiquitin-Editing Enzyme A20. Immunity. 2013; 39(3): 470-481.
12. Xu S, Liu X, Bao Y, Zhu X, Han C, Zhang P, Zhang X, Li W, Cao X. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nat Immunol. 2012; 13(6):551-559.
13. Liu X, Zhan Z, Li D, Xu L, Ma F, Zhang P, Yao H and Cao X. Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk. Nat Immunol. 2011; 12(5):416-424.
14. Ma F, Xu S, Liu X, Zhang Q, Xu X, Liu M, Hua M, Li N, Yao H, Cao X. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. Nat Immunol. 2011; 12(9):861-869.
15. Hou J, Lin L, Zhou W, Wang Z, Ding G, Dong Q, Qin L, Wu X, Zheng Y, Yang Y, Tian W, Zhang Q, Wang C, Zhang Q, Zhuang S, Zheng L, Liang A, Tao W, and Cao X. Identification of miRNomes in human liver and hepatocellular carcinoma reveals miR-199a/b-3p as a therapeutic target for hepatocellular carcinoma. Cancer Cell. 2011; 19(2):232-243.
16. Yang P, An H, Liu X, Wen M, Zheng Y, Rui Y, Cao X. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nat Immunol. 2010; 11(6):487-494.
17. Han C, Jin J, Xu S, Liu H, Li N, Cao X. Integrin CD11b negatively regulates TLR-triggered inflammatory response by activating Syk and promoting MyD88 and TRIF degradation via cbl-b. Nat Immunol. 2010; 11(8):734-742.
18. Wang C, Chen T, Zhang J, Yang M, Li N, Xu X, Cao X. The E3 ubiquitin ligase Nrdp1 preferentially promotes TLR-mediated type I interferon production. Nat Immunol. 2009; 10 (7):744-752.
19. An H, Hou J, Zhou J, Zhao Y, Xu H, Zheng Y, Yu Y, Liu S and Cao X. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting kinase IRAK-1. Nat Immunol. 2008; 9(5):542-550.
20. An H, Zhao W, Hou J, Zhang Y, Xie Y, Zheng Y, Xu H, Qian C, Zhou J, Yu Y, Liu S, Feng G, Cao X. SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production. Immunity. 2006; 25:919-928.
21. Zhang M, Tang H, Guo Z, An H, Zhu X, Song W, Guo J, Huang X, Chen T, Wang J, Cao X. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat Immunol. 2004; 5(11):1124-1133. (cover story)
On August 18, 2017, the “Health Silk Road” High-level Meeting was held in Beijing. This meeting was themed “Build the Belt and Road for Health and Share Health Development”. A lot of VIPs attended the...
On the morning of July 27, a face-to-face exchange activity themed “Building Partnership, Enhancing Exchanges, and Promoting Development” was initated by CAMS&PUMC and was held in Guizhou Medical...
On July 29, the dedication ceremony of the CAMS Key Laboratory for Adult Stem Cell Translational Research was held in Guizhou Medical University (GMU). Attending the ceremony were Li He, Vice Governor...
2nd CAMS Youth Science and Technology Innovation Forum Held in Chengdu, Attendees Visit the campus of Used-to-be CAMS’s Branch in Jianyang
In the afternoon of December 27, 2016, PUMC held the kickoff ceremony of centennial celebrations. More than 60 people attended the ceremony, including CAMS & PUMC President Xuetao Cao, Deputy Part...
On December 27, 2016, the first plenary session of the inaugural Council of PUMC Young Teachers Association was held in Beijing. PUMC President Xuetao Cao and Vice President Qin Zhang attended the eve...
The release ceremony of 2016 Top 100 Hospitals list and the 4th China Medicine Science Development Forum, sponsored by Chinese Academy of Medical Sciences (CAMS) and organized by CAMS Institute of Med...
At the invitation of CAMS & PUMC President Xuetao Cao, Prof. Hao Wu of Harvard Medical School paid a visit to CAMS & PUMC on December 21, 2016. An outstanding alumnus of PUMC, she was awarded ...
A delegation consisting of nine young and middle-aged scientists from the PUMCH, Fu Wai Hospital, Institute of Basic Medical Sciences, Institute of Materia Medica, and Institute of Pathogen Biology vi...
A ceremony marking the signing of the Cooperation Agreement on Building a Cross-provincial Network for the New Rural Cooperative Medical Care System (the "Agreement") was successfully held o...
On November 17-18, the CAMS & PUMC joined hands with the Nature Publishing Group to hold the 2nd Nature Advanced Writing Program in Beijing. Dr. Peter Gorsuch, former deputy editor of Nature, and ...
On November 10-11, the CAMS & PUMC joined hands with the Nature Publishing Group to offer the Nature advanced writing training course in Beijing.
The 74 CAMS & PUMC Academic Symposium was held on November 11, 2016, at Assembly Hall, Dongdan Santiao, Beijing, attended by more than 40 experts from PUMC, CAMS Cancer Hospital & Institute, I...
On November 7-9, 2016, Academician Xuetao Cao, president of the CAMS and PUMC, visited the Clinical Center (CC), National Institute of Allergy and Infectious Diseases (NIAID) and the National Cancer I...
Targeting AMPK: Basic Research and Drug Discovery - the 2nd Beijing International Conference was successfully held on November 8 and 9, 2016 at the Institute of Materia Medica of the CAMS.
Suzhou Mayor Futian Qu met with President Xuetao Cao and a delegation led by Nobel laureate Prof. David Baltimore, on November 4, 2016, at Suzhou Modern Building.
The third meeting of the first International Academic Advisory Committee of the Center of Systems Medicine & Suzhou Institute of Systems Medicine ("Institute of Systems Medicine") was he...
President Xuetao Cao, as Chairman of the Council for the CAMS Center of Systems Medicine and the Suzhou Institute of Systems Medicine (ISM), presided at the 4th meeting of the 1st Council at Suzhou Mo...
On the afternoon of November 4, 2016, the overall framework of the main building of the Institute of Systems Medicine (project in progress, Phase One), Chinese Academy of Medical Sciences, was complet...
On November 2, the International Forum on Frontiers in Medicine & the 3rd Forum on the Development of Medical Science in China was held to celebrate the 60th anniversary of the CAMS in the auditor...
On November 2, as one of the series of events held to commemorate the 60th anniversary of Chinese Academy of Medical Sciences, the Dialogue between Nobel Laureate and International Young Scientists wa...
On November 2, 2016, at the invitation of the CAMS & PUMC, a delegation of Guizhou Medical University attended a series of academic activities organized to celebrate the 60th anniversary of the CA...
The Lancet-CAMS Health Summit was successfully held in Beijing on October 30-31, 2016.
On October 28, the 60th anniversary ceremony of the CAMS was held in Beijing. Vice Premier Yandong Liu read out the congratulatory letter from Chinese President Jinping Xi and the instructions of Prem...
On the evening of October 30, CAMS presented a gala in celebration of the 60th anniversary of its founding in its auditorium. CAMS & PUMC leaders Xuetao Cao, Guoqin Li, Longshan Yao, Zhongwei Zhen...
Copyright @2012 All Rights Reserved.
